败血症-体外膜氧化评分在接受体外膜氧化支持败血症的患者中
Hongfu Fu1, Liangshan Wang, Yan Wang
1From the Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
概括
开发了一种新的败血症-ECMO评分来预测成人患者在败血症外体膜氧化 (ECMO) 上的死亡率. 这一分数基于年龄,血管活性无otropic分数,PaO2和乳酸清除,有助于风险分层和临床决策.
科学领域:
- 关键护理医学 关键护理医学
- 心肺支 提供心肺支
- 败血症管理管理
背景情况:
- 目前缺乏用于体外膜氧化 (ECMO) 的败血症患者的预测评分系统.
- 身体外膜氧化 (ECMO) 是严重败血症的重要生命支持,但预测结果仍然具有挑战性.
研究的目的:
- 开发和验证接受ECMO支持的成年败血症患者住院死亡率的预测评分系统.
- 在ECMO启动后24小时确定关键预后因素.
主要方法:
- 使用CSECLS注册数据库 (n=465) 的回顾性观察研究.
- 多变量后勤回归分析以确定住院死亡率的预后因素.
- 根据已识别的因素,结血症-ECMO评分的发展:年龄,血管活性无otropic评分 (VIS),PaO2,和乳酸清除.
主要成果:
- 在ECMO启动后24小时确定了四个预后因素:年龄,VIS,PaO2和乳酸清除.
- 败血症-ECMO评分显示,接收器操作特征曲线 (AUC) 下的面积为0.704 (95%CI:0.658-0.751).
- 定义了四个风险类别,较低得分类别的生存率明显更好 (p < 0.001).
结论:
- 败血症-ECMO评分有效地分层了成年败血症患者在ECMO上的风险.
- 这一分数可以改善预后信息的传播,并指导共享决策.
- 需要在不同种群中进一步验证败血症-ECMO评分.
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