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在多发性硬化症MRI中对比后敏感度加权成像改善了增强病变的检测

Pablo Naval-Baudin^1,2,3,4, Karen Pérez-Alfonso⁵, Albert Castillo-Pinar⁵

¹Radiology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Carrer de Feixa Llarga SN, 08907, Barcelona, Spain. pablo.naval.idi@gencat.cat.

Clinical neuroradiology

|March 7, 2025

概括

将后对比度敏感度加权成像 (SWI+C) 添加到标准对比度增强的T1加权成像 (T1WI+C) 中,可以改善多发性硬化症 (MS) 患者活跃炎症病变的检测. 这种增强的MRI方法也增加了观察者之间对MS病变识别的共识.

科学领域:

神经成像是一种神经成像.
放射学放射学是一门学科.
神经学神经学

背景情况:

磁共振成像 (MRI) 对于监测多发性硬化症至关重要.
与对比度增强的T1加权成像 (T1WI+C) 通过可视化血脑屏障的破坏来识别活跃的炎症病变.
敏感度加权成像 (SWI) 可以检测到MS特定的特征,而对比后的SWI (SWI+C) 可能会由于"T1透光效应"而显示增强对比的病变.

研究的目的:

为了评估SWI+C是否除了T1WI+C,还能改善在MS患者中增强病变的检测.
评估SWI+C和T1WI+C联合对病变检测和观察者间协议的影响.

主要方法:

对310名多发性硬化患者的MRI扫描进行了回顾性审查,这些扫描用3T扫描仪获得.
标准化的MRI协议包括T1WI+C和SWI+C.
由神经放射科医生和放射科医生进行的独立图像评估,将T1WI+C单独与T1WI+C加SWI+C进行比较.

主要成果:

神经放射学家在T1WI+C上检测到117个病变,在SWI+C上增加了123个病变.
这位住院医生在T1WI+C上检测到108个病变,在SWI+C上增加了121个病变.
通过综合成像方法,观察者间的一致性从0.981提高到1.00.

结论:

与单独使用T1WI+C相比,SWI+C始终提高了对活跃炎症性MS病变的检测.
添加SWI+C有助于改善观察者之间关于病变检测的共识.
标准化组合T1WI+C和SWI+C可能能够更早地检测MS疾病活动并改善监测,从而有可能优化治疗决策.

关键词:

基于加多的对比剂是基于加多的对比剂.磁共振成像技术磁共振成像技术多发性硬化症是多发性硬化症.根据敏感度加权的成像成像.用T1加权成像技术进行成像.

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