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Updated: May 23, 2025

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Quantitative Autonomic Testing
Published on: July 19, 2011
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"纯"自主性失败的表型
Elizabeth A Coon1, Negin Badihian2, Stuart J McCarter3
1Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Coon.elizabeth@mayo.edu.
概括
患有纯自主性衰竭的患者在正静性低血压开始时经常会出现其他自主性症状. 然而,梦想演示行为可能会在以后出现,并非所有患者都会进展到运动或认知能力下降.
科学领域:
- 神经学 神经学
- 自主性功能障碍 自主性功能障碍
- 合成核蛋白病变 (Synucleinopathies) 是一种同核蛋白病变.
背景情况:
- 纯自主性衰竭 (PAF) 是一种由自主神经系统功能障碍特征的同核病变.
- 了解PAF进展对于定义疾病及其与其他同核蛋白病变的关系至关重要.
研究的目的:
- 研究纯自主衰竭患者的症状时间表和自主特征.
- 识别患者的特征,这些患者随着时间的推移保持纯自主性失败表型.
主要方法:
- 在2001年至2011年期间,对202名被诊断为纯自主性衰竭的患者进行了回顾性审查.
- 个人随访和电话被用来评估症状发作和进展.
- 所有被纳入的患者都进行了自主反射查.
主要成果:
- 133名患者保持纯自主性衰竭,随访时间中位数为9.05年.
- 常见的自主性症状包括便秘 (45%),膀功能障碍 (59%),性功能障碍 (40%) 和温度调节功能障碍 (38%).
- 在52%的被评估患者中,报告了梦想表演行为,在正静性低血压7年后的中位数发作.
结论:
- 纯自主性衰竭患者通常在正静性低血压时出现症状.
- 梦想演戏行为可能在疾病的晚期表现出来.
- 很大一部分纯自主性衰竭患者甚至在长时间的随访中也不会出现运动或认知症状.
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