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创伤后脑损伤内分泌功能障碍:挑战和治疗方法

Zahra Soltani¹, Masoud Nazari², Meisam Babaei³

¹Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Afzalipor Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Acta neurologica Belgica

|March 7, 2025

概括

创伤性脑损伤 (TBI) 可以破坏下丘脑-垂体轴 (HPA),导致内分泌功能障碍,如下垂体. 治疗包括激素替代和探索植物性化合物,以获得更好的患者结果.

科学领域:

神经内分泌学神经内分泌学
公共卫生公共卫生

背景情况:

创伤性脑损伤 (TBI) 是一个重大的公共卫生问题,具有持久的后果.
创伤经常影响下丘脑-垂体轴 (HPA),破坏荷尔蒙平衡和整体平衡.

研究的目的:

审查TBI后的内分泌并发症,重点关注HPA功能障碍.
讨论TBI引起的内分泌疾病的当前和新兴治疗策略.

主要方法:

对TBI和内分泌系统影响研究的文献综述.
分析内分泌功能障碍,包括下垂体功能障碍及其临床表现.
检查治疗选择,包括激素替代疗法和新生物活性化合物.

主要成果:

在中度至重度的TBI患者中,多达40%的患者可能会出现下垂,导致显著的发病率.
常见的内分泌功能障碍包括上腺功能不充分,甲状腺功能低下和下腺功能低下,影响生活质量.
植物性化合物由于神经保护性和抗炎性质而显得有前途.

结论:

创伤诱导的内分泌疾病,特别是下垂体,需要全面的,多学科的护理.
个性化治疗计划,包括激素替代和新疗法,对于康复至关重要.
需要进一步的研究,以改善早期干预的诊断,治疗和生物标志物.

关键词:

内分泌功能障碍是指内分泌的功能障碍.草药是一种草药.激素替代疗法是一种激素替代疗法.脑下垂体 - 脑下垂体轴神经炎症是一种神经炎症.创伤性脑损伤是一种创伤性脑损伤.

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