认知功能和死亡率在与艾滋病毒和注射毒品使用老龄化的人群中
Damani A Piggott1, Shruti H Mehta, Leah H Rubin
1Johns Hopkins University, Baltimore, Maryland, USA.
AIDS (London, England)
|March 7, 2025
概括
认知障碍和虚弱预测HIV感染者注射药物的死亡率,独立于其他因素. 针对认知,虚弱和炎症可能会改善衰老的结果.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
背景情况:
- 认知障碍和虚弱在老年人群中很常见,特别是在艾滋病毒感染者 (PLWH) 中.
- 有限的研究涉及认知功能的决定因素和认知,虚弱和死亡率的相互作用,在注射毒品 (PWID) 感染艾滋病毒或处于艾滋病毒风险的人群中.
- 了解这些因素对于改善这个弱势群体的健康状况至关重要.
研究的目的:
- 研究艾滋病毒感染和不感染的PWID患者认知功能的决定因素.
- 检查这个人群中认知功能,脆弱性和死亡率之间的关系.
- 探索认知功能与炎症之间的关联.
主要方法:
- 在与静脉内体验 (ALIVE) 相关的艾滋病队伍中,进行了认知评估和脆弱性评估 (Fried标准).
- 炎症指数来自IL-6和可溶性TNF-α受体-1水平.
- 考克斯的比例危险模型被用来分析死亡风险.
主要成果:
- 高龄和危险的酒精使用与较差的认知功能 (处理速度,运动,整体) 有关.
- 减少认知功能 (处理速度,运动,全球) 和脆弱性独立预测死亡率增加.
- 认知缺陷与炎症增加有关.
结论:
- 认知障碍是一个显著的,独立的预测者死亡率在PLWH谁是PWID,不管脆弱或艾滋病毒的状态.
- 针对认知功能,虚弱和炎症的干预措施可能会提高PLWH和PWID的衰老结果.
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