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饮食中摄入维生素E和托科菲罗尔异形和慢性病的进展
Yanjun Zhang1, Ziliang Ye1, Yuanyuan Zhang1
1Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.
饮食维生素E及其特定形式,如β-和-托科菲罗尔,与慢性病 (CKD) 的进展和死亡率有多种关联. 在CKD患者中,alpha-tocopherol摄入量与这些结果没有显著的联系.
科学领域:
- 营养科学 营养科学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 在慢性病 (CKD) 患者中,饮食维生素E及其特定的托科菲罗尔异型对健康的影响尚不清楚.
- 这项研究调查了各种食托科菲罗尔异型对CKD进展和死亡率的不同影响.
研究的目的:
- 检查饮食维生素E和多科菲罗尔异型摄入量与CKD进展和全因死亡风险之间的关联.
- 测试假设,不同的托科菲罗尔异型在患有CKD的个体中具有不同的健康影响.
主要方法:
- 一项前性队列研究涉及3,791名患有慢性脏病的参与者,来自慢性脏衰竭队列 (CRIC) 研究.
- 评估了维生素E和多科菲醇异型的饮食摄入量,使用饮食历史问卷在基线,第二年和第四年进行评估.
- 慢性病进展被定义为估计膜过率下降50%或开始脏替代疗法;全因死亡率是次要结局.
主要成果:
- 在总维生素E摄入量与CKD进展风险和全因死亡率之间观察到L形关系.
- 饮食中的β-托科菲罗尔与CKD进展和死亡率有着L形的关联.
- 玛-托科菲罗尔与CKD进展呈现一个反向的J形关联,而三角-托科菲罗尔显示了一个U形关联. 阿尔法托科菲罗尔没有显示出任何显著的关联.
结论:
- 总维生素E摄入量在慢性病患者中显示出与CKD进展的L形关联.
- 不同的食托科菲罗尔异型与CKD进展有着不同的关系:β-托科菲罗尔 (L形),马-托科菲罗尔 (反转J形) 和三角形-托科菲罗尔 (U形).
- 在这个队列中,阿尔法-托科菲罗尔摄入量与CKD进展或全因死亡率没有显著的关联.
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