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咖啡消费可能抑制类风湿性关节炎患者的代谢综合征的发展 - - TOMORROW研究

Yoshinari Matsumoto¹, Yuko Sugioka², Masahiro Tada³

¹Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Japan.

Modern rheumatology

|March 7, 2025

概括

类风湿性关节炎 (RA) 并没有显著增加患代谢综合征 (MetS) 的风险. 然而,在RA患者中,定期饮用咖啡与较低的MetS发病率有关.

科学领域:

类风湿病学类风湿病学
代谢健康代谢健康
营养科学营养科学

背景情况:

代谢综合征 (MetS) 是一组增加心脏病,中风和2型糖尿病风险的疾病.
类风湿性关节炎 (RA) 是一种慢性炎症性疾病,可以影响关节和其他器官.
需要进一步调查RA,METS和饮食因素之间的关系.

研究的目的:

调查类风湿性关节炎 (RA) 与代谢综合征 (MetS) 的发展之间的关联.
探索饮食因素,特别是咖啡消费对RA患者MetS发展的影响.

主要方法:

预期队列研究设计,包括208名RA患者和205名匹配对照.
从2010年到2017年对MetS组件 (血压,脂质,葡萄糖,腰围) 的评估.
2011年评估的饮食摄入量,用于分析MetS发展的Cox比例危险建模.

主要成果:

类风湿性关节炎 (RA) 与患代谢综合征 (MetS) 的风险增加没有显著关联 (HR:0.86,95% CI:0.51,1.46).
在RA患者中,定期喝咖啡 (≥1杯/天) 与降低MetS发病风险显著相关 (HR:0.25,95%CI:0.10,0.62).
总咖啡消费量≥1杯/天显著与较低的MetS发病率相关 (HR:0.33,95%CI:0.13,0.82).

结论:

类风湿性关节炎 (RA) 不是发展代谢综合征 (MetS) 的重要危险因素.
咖啡摄入量可能在RA患者中起到保护性作用,防止MetS的发展.

关键词:

类风湿性关节炎类风湿性关节炎类风湿性关节炎咖啡咖啡咖啡咖啡咖啡饮食饮食饮食饮食生活方式生活方式代谢综合征代谢综合征营养营养营养营养

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