临床试验患者选择的主要结果:ENHANCE-AF结果调查
Randall S Stafford1, Eli N Rice2, Rushil Shah3
1Stanford University School of Medicine, Stanford Prevention Research Center, Stanford, California, United States of America.
PloS one
|March 7, 2025
概括
患有心房的患者更喜欢使用决策冲突量表 (DCS) 而不是决策后悔量表 (DRS) 来评估决策. DCS被选为ENHANCE-AF试验的主要终点.
科学领域:
- 心脏病学 心脏病学
- 医疗保健服务研究 医疗服务研究
- 患者为中心的结果.
背景情况:
- 前庭动 (AFib) 管理需要共享使用抗凝剂的决策.
- 以患者为中心的结果对于评估决策工具至关重要.
- 在ENHANCE-AF试验中,研究了一种用于AFib抗凝决定的数字工具.
研究的目的:
- 为了确定ENHANCE-AF试验中最合适的患者选择的初级结局.
- 为了比较患者在决策冲突量表 (DCS) 和决策后悔量表 (DRS) 之间的偏好.
- 检查影响结果选择的人口和临床因素.
主要方法:
- 一项对100名非膜性AFib.参与者的横截面调查.
- 参与者根据对决策经验的相关性对DCS (16项) 和DRS (5项) 进行了排名.
- 使用CHA2DS2VASc得分进行风险分层 (男性≥2,女性≥3).
- 多变量逻辑回归分析了与规模选择相关的因素.
主要成果:
- 77%的参与者更喜欢DCS而不是DRS (95%CI:68-85%).
- 所有子组都支持DCS.
- 与较低得分 (<5) (p=0.002) 相比,具有较高CHA2DS2VASc得分 (≥5) 的患者对DCS的偏好较弱.
结论:
- 决定性冲突量表 (DCS) 是心房的患者更喜欢使用的,用于测量决策的经验.
- DCS被选为ENHANCE-AF临床试验的主要终点.
- 患者的特征,特别是CHA2DS2VASc分数,影响结果测量选择.
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