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Updated: May 23, 2025

In vivo Assessment of Microtubule Dynamics and Orientation in Caenorhabditis elegans Neurons
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Published on: November 20, 2021

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帕拉莱明-1控制神经元子膜细胞骨架的纳米架构

Victor Macarrón-Palacios1,2, Jasmine Hubrich1, Maria Augusta do Rego Barros Fernandes Lima1

  • 1Department of Optical Nanoscopy, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany.

Science advances
|March 7, 2025
PubMed
概括

帕拉莱明-1 (Palm1) 组织神经元.

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Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
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Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
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Assembly of Complex Microtubule Structures

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Disassembly of Intermediate Filaments

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