汽车T细胞治疗胸部CT表现
Dorine de Jong1, Saheeb Ahmed2, Belinda Dsouza3
1RefleXion Medical Inc., Hayward, CA, USA.
Clinical imaging
|March 7, 2025
概括
流是CAR T细胞治疗后最常见的胸部CT发现. 新患者出现咳或呼吸障碍等症状可能表明这些放射性异常,需要临床注意.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 免疫治疗是一种免疫疗法.
背景情况:
- 化学抗原受体 (CAR) T细胞疗法是一种用于癌症治疗的新型免疫疗法.
- 评估CAR T细胞疗法的放射性影响对于患者管理至关重要.
研究的目的:
- 在接受CAR T细胞治疗的患者中识别和描述最常见的胸部计算机断层扫描 (CT) 发现.
- 为了将CT表现与临床症状和患者数据相关联.
主要方法:
- 在CAR T细胞治疗前后进行胸部CT检查的349名患者的回顾性分析.
- 对患者病历进行审查,以获取人口统计和临床信息.
- 两个心胸放射科医生对CT扫描进行独立审查,以确定新的放射性特征.
主要成果:
- 流是最常见的CT表现 (26.3%的患者).
- CT异常与呼吸不全和咳的可能性增加有关 (p < 0.05).
结论:
- 在接受CAR T细胞治疗的患者中,新出现的症状可以表明放射性异常.
- 临床医生应在CAR T细胞治疗后的有症状的患者中保持对胸腔液的高度怀疑指数.
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