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双A暴露和12岁以下儿童的神经发育障碍和问题:系统性审查和元分析

Jianghui Zhang¹, Minglu Yuan¹, Ying Liu²

¹Department of Medical Statistics, School of Public Health, Sun Yat-sen University, #74 Zhongshan Road 2, Guangzhou 510080, China; Center for Migrant Health Policy, Sun Yat-sen University, #74 Zhongshan Road 2, Guangzhou 510080, China.

Journal of hazardous materials

|March 7, 2025

概括

双甲 (BPA) 暴露与儿童的神经发育障碍有关. 对于智力障碍,自闭症谱系障碍和ADHD等疾病,男孩的风险更高.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
儿科儿科儿科

背景情况:

双甲 (BPA) 暴露对儿童神经发育的担忧日益增加.
现有的关于BPA和12岁以下儿童的神经发育障碍 (NDP) 的证据不一致.
需要进行全面的系统审查和元分析来澄清这种关联.

研究的目的:

系统地审查和元分析双A (BPA) 暴露与儿童神经发育障碍 (NDP) 之间的关联.
调查BPA暴露与NDPs之间的关联中的潜在性别差异.
提供关于BPA对儿童大脑健康的影响的强有力的证据.

主要方法:

在8个数据库中进行系统的文献搜索,截至2024年10月11日.
包括12岁以下儿童的流行病学观察性研究.
使用多层随机效应模型进行元分析,并进行元回归和偏差分析.

主要成果:

包括32项涉及15669名参与者的研究.
在所有儿童中,BPA暴露与智力障碍,自闭症谱系障碍 (ASD),注意力缺陷多动症障碍 (ADHD) 和沟通障碍有关.
观察到的性别差异:BPA与男孩的智力障碍,自闭症,多动症和运动障碍有关;女孩的智力障碍和多动症.

结论:

暴露于BPA与儿童神经发育障碍的风险增加有关.
男孩似乎特别容易受到BPA的神经发育影响.
研究结果强调了将BPA视为儿童大脑健康的风险因素的重要性.

关键词:

双乙烯 A 是一种双乙烯.孩子孩子孩子孩子进行元分析分析.神经发育障碍神经发育障碍神经发育问题神经发育问题系统审查是系统的审查.

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