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Updated: May 23, 2025

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SUMO4促进了DNA双链断裂修复所需的SUMO脱

Alexander J Garvin1, Alexander J Lanz2, George E Ronson2

  • 1Birmingham Centre for Genome Biology and Department of Cancer and Genomic Sciences, School of Medicine, College of Medicine and Health, University of Birmingham, Birmingham B15 2TT, UK; SUMO Biology Laboratory, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

Molecular cell
|March 7, 2025
PubMed
概括

通过调节SUMOylation,SUMO4蛋白质可以防止过度的DNA损伤反应. 它增强了SENP1的活动,确定SUMO4是DNA修复信号的关键调节器.

关键词:
修复DNA的修复DNA的修复RAP80 RAP80是指80年级的一项活动.这就是SENP1的意义.这就是所谓的SUMO.在 SUMO4 里,你会看到 SUMO4.同类的重组组合.

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