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相关概念视频

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Prevalence and Incidence01:08

Prevalence and Incidence

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In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
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Probability Laws01:49

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Overview
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Oogenesis02:07

Oogenesis

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Regression Toward the Mean01:52

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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
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相关实验视频

Updated: May 23, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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连续怀孕中早产的复发风险基于其亚型.

Iris T Smith1, Michael J Fassett2,3, David A Sacks4

  • 1Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California.

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概括

以前的早产 (PTB) 显著增加了复发风险,特别是在相同的亚型. 非西班牙裔黑人和亚洲/太平洋岛屿妇女面临更高的风险,突出了差异和需要有针对性的干预措施.

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科学领域:

  • 产科和妇科 产科和妇科
  • 围产期健康 围产期健康
  • 公共卫生 公共卫生

背景情况:

  • 过早分娩 (PTB) 是一个主要的公共卫生问题,具有显著的产科和围产后果.
  • 患有PTB病史是已知的复发风险因素,但种族/种族,妊娠年龄,PTB亚型和妊娠间隔 (IPI) 的影响需要进一步调查.

研究的目的:

  • 评估包括种族/种族,妊娠年龄,PTB亚型 (自发/指示) 和IPI在内的因素如何改变PTB复发的风险.
  • 为了确定与PTB复发相关的特定风险因素和差异,在一个大,多样化的人口中.

主要方法:

  • 对单子妊娠 (2009-2022) 的回顾性队列研究,使用来自南加州凯泽永久医院的电子健康记录数据.
  • 包括两个 (82,610) 和三个 (14,925) 怀孕的妇女.
  • 自然语言处理用于PTB亚型识别 (sPTB, iPTB);逻辑回归用于风险评估 (aOR,95%CI).

主要成果:

  • 第一次PTB增加了第二次PTB的风险六倍 (23.29%对4.98%).
  • 同一个PTB亚型 (sPTB:aOR 5.32; iPTB:aOR 8.26) 的复发风险更高.
  • 与非西班牙裔白人相比,非西班牙裔黑人和亚洲/太平洋岛屿妇女的复发风险更高;在前两次怀孕中,PTB的风险大幅增加 (aOR 14.59).

结论:

  • PTB复发风险显著增加,特别是在同一亚型和种族/族群之间,这表明持续存在的差异.
  • 早期妊娠年龄 (20-33周) 的分娩显示出明显更高的复发.
  • 调查结果强调需要进行亚型特定分析和有针对性的干预措施,以解决PTB复发差异.