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Updated: May 23, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
美国CKD人口中心血管疾病风险估计使用PREVENT方程
Carl P Walther1, L Parker Gregg2, Sankar D Navaneethan3
1Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.
2023年美国心脏协会 (AHA) 预测心血管疾病风险 (CVD) 事件 (PREVENT) 方程估计慢性病 (CKD) 患者的心血管疾病风险较低,与较旧的模型相比. 尽管风险估计较低,但许多符合条件的CKD患者没有接受他类药物治疗.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD) 风险预测对于预防至关重要.
- 传统的风险方程往往忽略了功能.
- 2023年AHA PREVENT方程包括脏测量 (eGFR,UACR) 在内.
研究的目的:
- 在美国慢性病 (CKD) 患者中估计心血管疾病风险,使用2023年AHA PREVENT方程.
- 将PREVENT方程风险估计与2013年AHA/ACC聚合队列方程 (PCE) 进行比较.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2013-2020) 进行的横截面研究.
- 包括40至75岁的患有慢性脏病 (eGFR<60或UACR≥30) 且以前没有心血管疾病的个人.
- 利用调查方法来代表美国CKD人口.
主要成果:
- 与PCE相比,PREVENT方程估计10年动脉样硬化心血管疾病 (ASCVD) 风险较低 (8.8%), (增长5.2个百分点).
- 平均10年心力衰竭风险为11.6%,心血管疾病风险为15.3%.
- 63.4% (AHA指南) 到85.9% (KDIGO指南) 的CKD患者有资格接受他类药物治疗,但接受治疗的不到一半.
结论:
- 与PCE相比,PREVENT方程为CKD患者提供了较低的ASCVD风险估计.
- 在符合条件的CKD患者中,他类药物治疗的吸收存在显著差距.
- 这突出了在CKD人口中预防心血管疾病的关键机会.
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