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总体和中心肥胖都与刺激性肠综合征的风险增加有关:一项大规模前性队列研究
Shuang Yu1, Yesheng Zhou1, Si Liu1
1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China; State Key Laboratory for Digestive Health, and National Clinical Research Center for Digestive Diseases, Beijing, China.
肥胖,无论是一般的还是中心的,都与患上易怒肠综合征 (IBS) 的风险更高有关. 控制体重对于预防IBS可能很重要.
科学领域:
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 肥胖是一个重要的全球健康问题.
- 肥胖和易怒肠综合征 (IBS) 之间的联系需要进一步调查.
研究的目的:
- 系统地评估一般和中心肥胖指标与新发IBS风险之间的关联.
- 分析来自大量基于人口的队列的数据,以了解这种关系.
主要方法:
- 包括没有先前存在的IBS,乳病,炎症性肠病或癌症的参与者.
- 使用身体质量指数 (BMI),腰围和内脏脂肪组织体积来评估肥胖.
- 采用Cox的比例危险模型来确定事件IBS的风险.
主要成果:
- 肥胖与与正常BMI相比,患IBS的风险增加7%.
- 包括腰围和内脏脂肪组织在内的中心肥胖度指标显示,与IBS风险有显著的积极关联 (风险高14-35%).
- 敏感性和子组分析证实了这些发现,表明肥胖和IBS之间存在一致的联系.
结论:
- 一般和中心肥胖都是发展IBS的危险因素.
- 有效的肥胖管理策略可能在IBS预防中发挥作用.
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