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体外模型:它们能解开癌细胞转移的复杂性吗?

Stefanos Pafitanis¹, Lefteris C Zacharia², Andreas Stylianou³

¹Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus; Cancer Metastasis and Adhesion Group, Basic and Translational Cancer Research Center (BTCRC), European University Cyprus, Nicosia, Cyprus.

Biochimica et biophysica acta. Reviews on cancer

|March 7, 2025

概括

本综述强调了研究癌症转移的先进体外模型. 这些三维 (3D) 系统更好地模仿瘤微环境,有助于开发新的抗转移疗法.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
生物技术是生物技术.

背景情况:

转移仍然是全球癌症死亡的主要原因.
研究患者的转移是困难的,需要改进的实验模型.
现有的体外和体外模型在重复转移方面存在局限性.

研究的目的:

审查目前研究癌细胞转移的方法.
强调新的体外系统,更好地模拟转移过程.
讨论先进模型如何改善对转移的理解和治疗.

主要方法:

对当前癌症转移研究方法的分析.
专注于新开发的三维 (3D) 试管系统.
包括考虑瘤3D结构和微环境相互作用的模型.

主要成果:

先进的3D生物打印,组织模型,微流体和球体生成提供了改进的转移建模.
这些系统包含了关键因素,如细胞外基质和细胞与细胞相互作用.
模型的选择取决于具体的研究问题和癌症类型.

结论:

新的体外模型显著增强了体内转移过程的复述.
这些复杂的模型对于推进转移的研究至关重要.
这些模型的进一步开发和应用有望为预防癌症扩散提供新的治疗策略.

关键词:

三维模型是3D模型.生物打印是一种生物打印技术.细胞迁移细胞迁移这是入侵的入侵.微流体学微流体学新生病是什么?新生病新生病是什么?

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