红细胞输血后的氨酸乙醇清除量
Olivia C Iverson1, Karlie A Smith2, Pragya Sharma3
1Mayo Medical School, Mayo Clinic Arizona, United States.
输血红细胞 (pRBC) 输血后的脂乙醇 (PEth) 阳性是常见的. 建议使用更高的PEth值进行解释,因为输血后的动力学与内源性清除有所不同.
科学领域:
- 临床化学 临床化学
- 输血医学 输血医学
- 毒理学 毒理学 毒理学
背景情况:
- 脂乙醇 (PEth) 是长期饮酒的生物标志物.
- 对于评估禁欲,尤其是移植候选人来说,PEth是至关重要的.
- 包装红细胞 (pRBC) 输血可以引入外源性PEth,可能导致混结果.
研究的目的:
- 为了评估PEth16:0/18: 1阳性的动力学和持续时间,在pRBC输血后.
- 确定pRBC输血对接受者的PEth水平的影响.
主要方法:
- 接受pRBC的肝移植接受者 (n=76) 在输血后两周内被监测PEth 16:0/18:1度.
- 分析了PEth清除动力学,并对血红蛋白和血红素进行了调整.
主要成果:
- 近一半 (48.7%) 的接受者在输血后显示PEth≥10 ng/mL.
- PEth半衰期是可变的 (平均为6.6天),随着血红素/血红蛋白校正而改善 (平均为4.6-4.9天).
- 清除到<10 ng/mL,范围从<1到>19天;40.5%在5天内清除.
结论:
- 在pRBC输血后的PEth阳性比以前所认为的更频繁.
- 较高的PEth值 (例如20 ng/mL) 是对解释的建议.
- 由于潜在的PRBC影响,移植团队必须谨慎地解释PEth在输血后2-3周内.
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