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肌反应性入侵前线区域 (SARIFA),瘤免疫微环境,以及结直肠癌的存活率

Vilja V Tapiainen¹, Päivi Sirniö¹, Hanna Elomaa^2,3

¹Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.

British journal of cancer

|March 7, 2025

概括

肌反应性入侵前部区域 (SARIFA) 是结肠直肠癌的可重现的预后标志物. 阳性SARIFA瘤与免疫抑制的微环境和较差的生存结果相关.

科学领域:

在瘤学瘤学.
癌症免疫学癌症免疫学
瘤微环境研究研究

背景情况:

干细胞反应性侵袭前部区域 (SARIFA) 是胃肠道癌的潜在预后标志物,代表了瘤细胞与脂肪细胞的直接接触.
这项研究调查了SARIFA与免疫抑制瘤微环境之间的关联.

研究的目的:

评估SARIFA作为结直肠癌的独立预后标志物.
确定SARIFA状态与瘤微环境中的免疫细胞透之间的关系.

主要方法:

在两个大型结直肠癌队列 (N=1876) 中评估了SARIFA状态.
使用多变量考克斯回归进行的生存分析.
免疫细胞密度通过多重化和常规免疫组织化学与数字图像分析量化.

主要成果:

在两个队列中,SARIFA阳性独立地与较短的癌症特异性存活率相关 (HRs > 1.75,P < 0.0001).
在SARIFA阳性瘤中,CD3+T细胞,粒细胞,M1巨细胞和成熟单细胞的密度较低.
相反,SARIFA-阳性与M2巨细胞和不成熟的单细胞细胞密度更高有关.

结论:

SARIFA状态是结直肠癌的高度可复制和独立的预后因素.
萨里法-阳性与抗瘤免疫力降低和转向原始M2巨细胞表型的转变相关.

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