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表观遗传学在儿童癌症病原和耐药性中的作用
Jia Yu Leung1,2,3, Hsin Yao Chiu1, Reshma Taneja4
1Department of Physiology, Healthy Longevity and NUS Centre for Cancer Research Translation Research Program, Yong Loo Lin School of Medicine, National University of Singapore (NUS), 2 Medical Drive, MD9, Singapore, 117593, Republic of Singapore.
表观遗传改变驱动儿科癌症的发展和复发,提供潜在的诊断生物标志物. 针对这些表观遗传漏洞可能会提高儿童瘤的生存率.
科学领域:
- 儿科瘤学 儿科瘤学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
背景情况:
- 儿科瘤发生与细胞特异和分化在发育过程中的错误有关,这些错误是由表观遗传信号控制的.
- 儿童癌症的低体质突变计数表明失调的染色体景观是主要的驱动因素.
- 表观遗传失调源于突变,改变的基因组和基因表达,DNA甲基化变化和非编码RNA失调.
研究的目的:
- 审查儿科癌症瘤发生和复发中的表观遗传变化.
- 探索表观遗传改变作为诊断生物标志物的潜力.
- 讨论在临床试验中的表观遗传药物,用于侵袭性儿科癌症.
主要方法:
- 关于儿科癌症表观遗传变化的文献综述.
- 对表观遗传失调机制的当前研究进行分析.
- 对儿科瘤学中的表观遗传药物的临床试验数据的检查.
主要成果:
- 表观遗传失调,包括DNA甲基化和非编码RNA变化,是儿童癌症的关键因素.
- 表观遗传变化显示为早期检测和监测的诊断生物标志物具有前途.
- 几种表观遗传药物正在研究治疗侵袭性儿科癌症.
结论:
- 表观遗传变化对于儿科癌症的发展,复发以及作为潜在的生物标志物至关重要.
- 针对儿科癌症的特定表观遗传漏洞可以提高治疗效率.
- 利用表观遗传标提供了一个有希望的策略,以提高高风险儿科癌症的无复发生存率.
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