相关实验视频

Updated: May 23, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

在状细胞疾病研究中使用种族和民族

Aida S Kidane Gebremeskel^1,2, Minke A Rab^3,4, Erik D van Werkhoven³

¹Department of Pediatrics, Pediatric Hematology, Erasmus Medical Center, Dr. Molewaterplein 40, Rotterdam, 3015 GD, The Netherlands. aida.kidane.sci@gmail.com.

BMC medical research methodology

|March 7, 2025

概括

这项研究研究了如何使用民族种族类别 (ERC) 作为状细胞疾病 (SCD) 研究中的混因素. 调查结果揭示了不一致的做法,以及ERC如何应用的缺失细节,这可能会在生物医学研究中引入偏见.

科学领域:

生物医学研究伦理学
人口健康人口健康
遗传学和基因组学遗传学和基因组学

背景情况:

民族种族类别 (ERC) 经常被用作生物医学研究中的混因素.
状细胞疾病 (SCD) 经常被种族化,使其研究成为检查ERC运营的关键领域.
在广泛的ERC标签下聚合多样化的群体引发了人们对其作为混剂的有效性的担忧.

研究的目的:

调查ERC作为生物医学研究中的混因子的运行实践,使用SCD作为模型.
在SCD研究中分析ERC调整的利用情况,区域差异和方法细节.
发现报告和遵守ERC在研究中的使用指南的差距.

主要方法:

对1105项关于状细胞病的全球研究进行了系统分析.
收集关于ERC调整使用情况,区域差异,ERC标签,匹配理由和确定方法的数据.
统计分析以确定ERC调整率的显著区域差异.

主要成果:

在分析的SCD研究中,28%使用了种族类别调整,观察到区域差异很大 (p < 0.001).
西方研究表明,与其他地区相比,ERC调整率更高.
报告往往不完整,经常遗漏ERC标签 (通常是"非洲"或"黑人"),匹配的理由 (仅提供7%) 和确定方法 (70%未指明).

结论:

目前在生物医学研究中,特别是SCD研究中,ERC作为混因素的运行实践缺乏标准化和透明度.
不一致的ERC应用和不充分的报告引起了人们对潜在的研究偏见,结果的误解和种族刻板印象的延续的担忧.
遵守ERC运营的明确指导方针对于确保研究完整性和减轻健康不平等至关重要.

关键词:

混调整是指混调整.民族身份民族身份种族-种族类别.种族种族种族种族状细胞疾病是一种状细胞疾病.

更多相关视频

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Published on: February 19, 2017

相关概念视频

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Pedigree Analysis

Pedigree Analysis

Genetic Lingo

Genetic Lingo

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Genetic Variation

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...

Incomplete Dominance

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.