分析基于ClinicalTrials.gov数据库的MASLD干预性临床试验登记
Hui Du1, Jihan Huang2, Youhua Wang1
1Department of Infectious, Longhua Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, #725 Wanping South Road, Xuhui District, Shanghai, 200032, People's Republic of China.
BMC gastroenterology
|March 7, 2025
概括
这项研究分析了与代谢功能障碍相关的脂肪性肝病 (MASLD) 临床试验. 目前的研究重点是针对炎症和新陈代谢的药物干预,为未来的MASLD治疗开发提供了洞察力.
科学领域:
- 肝病学和临床试验设计
- 药理学研究和药物开发
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 发病率在全球范围内正在上升.
- 目前正在进行广泛的药物研究和临床试验,以开发MASLD疗法.
研究的目的:
- 检查MASLD疗法的设计原则和研究目标.
- 为临床试验参与者和MASLD研究中的决策者提供指导.
主要方法:
- 在clinicaltrials.gov的系统搜索中,发现了1209个针对MASLD的干预性临床试验.
- 根据临床阶段,设计,干预和结果指标来评估试验.
主要成果:
- 关于MASLD的研究显著增加,在2013-2024年期间注册了83.54%的试验.
- 平行设计 (72.21%) 主导着MASLD试验,主要结局包括组织学改善,脂肪含量和不良事件.
- 药物干预侧重于代谢/能量平衡,炎症和脂质减少,针对PPAR,FXR,ACC和GLP-1.
结论:
- 全球MASLD临床试验主要以药物为重点.
- 针对炎症和代谢途径的干预仍然是MASLD药物开发的主要策略.
更多相关视频
07:40A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
4.1K
06:55Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
14.3K
相关概念视频
01:12Hazard Ratio
73
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
73
01:19MALDI-TOF Mass Spectrometry
4.7K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
4.7K