母体calprotectin血水平与胎盘断裂的相关性
Neval Cayonu Kahraman1, Mehmet Obut2, Ozgur Arat2
1Perinatology Department, University of Health Sciences Etlik Zübeyde Hanım Women's Health Care, Training and Research Hospital, Ankara, Turkey. nevalcayonu@gmail.com.
BMC pregnancy and childbirth
|March 7, 2025
概括
在经历了胎盘断裂的妇女中,母亲的血清calprotectin水平显著更高. 这一发现表明,calprotectin可能作为这种妊娠并发症的潜在生物标志物.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 临床化学 临床化学
背景情况:
- 胎盘断裂是一种严重的产科并发症,具有严重的孕产妇和胎儿风险.
- 胎盘断裂的早期检测和准确诊断仍然是产科护理中的关键挑战.
- 胎盘断裂的生物标志物是必要的,以提高诊断的准确性和患者的结果.
研究的目的:
- 为了研究母体血calprotectin水平和胎盘断裂之间的关联.
- 为了确定calprotectin是否可以作为胎盘断裂的诊断标记.
主要方法:
- 一项前性研究涉及33名胎盘断裂的孕妇和48名匹配的对照.
- 排除标准的应用是为了确保同质的研究人群,排除了诸如孕前和感染之类的疾病.
- 使用免疫测试方法测量母亲血清calprotectin度.
主要成果:
- 两组之间在母亲的年龄,怀孕,平价或BMI方面没有显著差异.
- 在胎盘断裂组中,母亲的血清calprotectin水平显著升高 (p < 0.001).
- 91.95 ng/ml的最佳calprotectin截止值显示出良好的诊断性能 (AUC 0.763).
结论:
- 这项研究显示,较高的母体血清calprotectin水平和胎盘断裂之间存在显著的关联.
- 升高的calprotectin可能表明胎盘炎症或与断裂相关的损伤.
- 孕产妇的calprotectin需要进一步调查,因为它可能是胎盘断裂的非侵入性生物标志物.
更多相关视频
11:44A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
Published on: September 27, 2017
11.3K
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
3.7K
相关概念视频
01:15Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...