相关实验视频
Updated: May 23, 2025
10:42
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
Published on: February 27, 2019
9.3K
抗微生物的生物活性,输送系统和临床翻译状态和挑战
Sainan Zheng1, Yuhan Tu1,2, Bin Li2
1Department of Pharmacy, Yueqing Third People's Hospital, Wenzhou, 325604, People's Republic of China.
Journal of translational medicine
|March 7, 2025
概括
抗微生物 (AMP) 显示出对抗抗生素耐药性的承诺,但面临着交付挑战. 新型药物输送系统,如纳米颗粒和水凝,提高AMP的稳定性和生物可用性,用于临床使用.
科学领域:
- 生物化学和分子生物学
- 药物输送系统 药物输送系统
- 传染性疾病 传染性疾病
背景情况:
- 抗生素耐药性构成了全球严重的健康威胁,需要新的抗菌剂.
- 抗微生物 (AMP) 是具有广泛生物活性的关键先天性免疫成分.
- AMP的临床应用受到细胞毒性和不良的药理动力学限制.
研究的目的:
- 审查AMP机制,优势和局限性.
- 评估药物输送系统,以提高AMP的稳定性和生物可用性.
- 突出基于AMP的治疗方法的临床进展和挑战.
主要方法:
- 关于AMP和药物输送系统的综合文献综述.
- 系统评估纳米粒子和水凝用于AMP交付.
- 对AMP药物的最新临床数据和翻译挑战的分析.
主要成果:
- AMP具有多种抗微生物和抗炎性质.
- 纳米粒子和水凝提高AMP的稳定性,生物可用性和向性传递.
- 一些基于AMP的药物正在临床试验中,面临着重大翻译障碍.
结论:
- 药物输送系统对于克服AMP限制至关重要.
- 需要进一步的研究来应对将AMP转化为临床实践的挑战.
- 作为下一代抗微生物药物,AMP具有显著的潜力.
相关概念视频
01:23Antimicrobial Proteins
857
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
857
01:16Drug Delivery: Overview
270
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
270