左侧垂体结构连接在叶中介于典型和非典型的语言横向性
Salvatore Citro1, Sam S Javidi2, Ankeeta Ankeeta2
1IRCCS SYNLAB SDN, Naples, Italy.
Epilepsia
|March 8, 2025
概括
左叶中的白质连接对于患有左叶 (TLE) 的人的语言处理至关重要. 这些途径支持典型的左半球语言主导和适应性,非典型的语言组织在TLE患者.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 神经成像是一种神经成像.
背景情况:
- 左叶 (TLE) 可以导致改变或典型的语言横向化.
- 了解白质路径的完整性是保持TLE语言功能的关键.
研究的目的:
- 研究健康个体和TLE患者的白质完整性和语言横向化之间的关系.
- 在典型与非典型的横向化模式中,根据白质结构区分语言组织.
主要方法:
- 结合基于任务的功能磁共振成像 (fMRI) 和扩散指标.
- 在41名TLE患者和51名健康参与者 (HPs) 中,比较了语言横向性和白质连接性.
- 评估了典型的左半球和非典型 (双边/右偏) 语言侧面化之间的差异.
主要成果:
- 在TLE中,典型的额头和部语言横向化显示出对左叶白质连接的依赖性较小.
- 具有典型横向化的健康参与者依靠左侧顶叶连接来进行时间语言组织.
- 具有非典型横向化的TLE患者表现出由左侧叶连接介导的正面和叶语言组织.
结论:
- 左叶叶白质连接对于维持典型的左半球语言处理和在TLE中形成适应性,非正规的语言不对称性至关重要.
- 在TLE中评估语言技能需要考虑白质结构对横向化的影响.
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