视觉结局包括治疗儿科光学通路质瘤后的视野缺陷:一项全国性队列研究
C A M Bennebroek1,2, J van Zwol1, M C Montauban van Swijndregt1
1Department of Ophthalmology, University of Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Acta ophthalmologica
|March 8, 2025
概括
几乎五分之一的患有光通路质瘤 (OPG) 的儿童经历了严重的视力丧失或长期失明. 早期治疗 (年龄在2岁以下) 和下丘脑参与增加了儿科OPG患者的风险.
科学领域:
- 眼科医生 眼科 眼科
- 儿科瘤学 儿科瘤学
- 神经瘤学神经瘤学
背景情况:
- 视通路质瘤 (OPG) 是影响视神经和大脑的瘤.
- 治疗儿科OPG可能会导致长期视力障碍.
研究的目的:
- 评估各种儿科OPG治疗后的长期视力障碍和视野 (VF) 缺陷.
- 确定这些儿童严重视力障碍或失明的预后因素.
主要方法:
- 一项全国性的回顾性队列研究分析了1995-2018年的数据.
- 分析了最佳校正视敏度 (BCVA) 和VF测试结果,以确定严重视力损伤或失明.
- 使用统计分析确定了预后因素.
主要成果:
- 严重的视力损伤或失明 (>1.0 LogMAR) 影响了18.8%的患者和34.6%的长期眼睛.
- 在80%的被评估的眼睛中发现了单眼VF缺陷,主要是半视.
- 在2岁之前开始治疗和下丘脑参与是严重视力丧失的独立预后因素.
结论:
- 长期严重的视力障碍或失明影响了大量的儿科OPG患者.
- 视野缺陷很常见,但VF数据在研究中被低估.
- 早期治疗 (2岁以下) 和瘤位置是视力丧失的关键风险因素.
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