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胃calprotectin作为一个生物标志物,用于评估克罗恩氏病在患有口腔的患者的活性
Kavindra Abeyratne1, Martin Harb2, Karen Bensted3
1Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
胃calprotectin不是一个可靠的生物标志物,克罗恩氏病活动在患有口腔的患者. 在这个患者群体中,C-反应蛋白对识别炎症更有希望.
科学领域:
- 胃肠病学和炎症性肠病研究
背景情况:
- 便中的calprotectin是下胃肠道炎症的公认生物标志物.
- 关于calprotectin在口腔排泄物中测量的有效性的数据有限.
研究的目的:
- 为了评估胃calprotectin在检测活跃克罗恩氏病的表现,在个体与一个结肠直肠或结肠直肠直肠.
主要方法:
- 在澳大利亚的三个地点发现了克罗恩氏病和口腔静脉瘤的患者.
- 通过成像或内镜测定了疾病活动,采样后三个月内进行.
- 在活跃和不活跃的疾病组之间比较了胃calprotectin水平;还评估了C-反应蛋白和哈维·布拉德肖指数.
主要成果:
- 胃calprotectin对活跃克罗恩病的敏感性很差 (33%).
- 在活跃的 (17μg/g) 和不活跃的 (61μg/g) 疾病之间,胃calprotectin水平的中位数没有显著差异.
- 在活跃疾病中,C反应蛋白的含量较高,但哈维布拉德肖指数没有差异.
结论:
- 胃calprotectin不是克罗恩病活动的可靠指标,在患有口腔的患者.
- 在这种人群中,C-反应蛋白似乎是一个更可靠的疾病活性生物标志物.
- 进一步的研究是必要的,以找到更好的生物标志物,为口腔患者.
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