在接近生命末期的晚期癌症患者中,预防性药物治疗抑郁症
Jane McKenzie1,2, Catherine Dunn1, Grace Gard1
1Personalised Oncology Division, Walter and Eliza Hall Institute, Melbourne, Victoria, Australia.
Internal medicine journal
|March 8, 2025
概括
许多晚期癌症患者在预防性药物处方 (PMP) 上继续使用它们,尽管益处有限,风险高. 临终症患者在息治疗中的处方机会经常被错过.
科学领域:
- 在瘤学瘤学.
- 抚慰性护理是一种缓解性护理.
- 老年医学 老年医学
背景情况:
- 患有晚期癌症和预期寿命有限的患者经常接受预防性药物处方 (PMP),其益处不确定,风险增加.
- 这种做法可能会导致脆弱人群的多药性和不良事件.
研究的目的:
- 评估在接受息护理瘤学治疗的患者中PMP的发生率.
- 为了确定绝症癌症患者的抑郁的机会和模式.
主要方法:
- 缓和护理瘤学入院的回顾性审查.
- 在首次安慰性护理入院时分析药物数据.
- 检查抑郁症的发病率和患者的结果 (包括死亡时间).
主要成果:
- 在初始息护理入院时,观察到高比例的PMP (69%).
- 尽管住院患者的抑郁率很高 (88%),但一些患者的PMP仍在继续.
- 住院后的中位生存时间很短 (16天),表明患有绝症的人群.
- 晚期瘤发病率与最后一次全身治疗或之前的息治疗参与以来的时间没有显著相关.
结论:
- 医生和多学科团队可能会错过在绝症癌症患者中不再处方药物的机会.
- 需要进一步的干预,以优化晚期癌症息护理中的药物管理.
- 专注于抑郁症可以改善生活质量,并减少临终期患者的药物相关风险.
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