相关实验视频
Updated: May 23, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.5K
亨特研究:甲状腺刺激激素 (TSH) 的长期在人体内变化
Arne Åsberg1, Marius Berg1,2, Gunhild Garmo Hov1,2
1Department of Clinical Chemistry, St. Olav's Hospital, Trondheim, Norway.
概括
血清甲状腺刺激激素 (S-TSH) 的长期生物变异估计使用十多年的数据来自超过16000名健康个体. 该研究发现S-TSH在受试者内的生物变异 (CVI+A) 为21-23%.
科学领域:
- 临床化学 临床化学
- 内分泌学 在内分泌学.
- 生物统计学 生物统计学
背景情况:
- 对于血清甲状腺刺激激素 (S-TSH) 的长期体内生物变异 (CVI) 存在有限的数据.
- 像EFLM生物变异数据库这样的数据库中以前的估计是基于较短的观察期 (长达一年).
研究的目的:
- 估计S-TSH.的长期主体内生物变异,包括分析变异 (CVI+A).
- 为长期提供关于S-TSH生物变异的可靠数据.
主要方法:
- 利用了来自特伦德拉格健康研究 (HUNT) 的16976名健康个体的数据,其中S-TSH测量约隔10.6年.
- 使用refineR软件识别非病态亚群,并使用百分比平均值 (DPM) 的差异估计CVI+A.
- 该方法在测量之间对系统偏差的稳定性进行了验证.
主要成果:
- 据估计,S-TSH的CVI+A在不同年龄和性别组中为21-23%.
- 考虑到分析变化 (CVA) 表示CVI仅比CVI+A低0.1-0.8%.
- 这些发现与现有元分析报告的CVI (12-29.3%) 范围一致.
结论:
- 这项研究提供了S-TSH生物变异的第一个长期估计,建立了21-23%的CVI+A.
- 这些结果为解释S-TSH测试结果和理解随时间变化的甲状腺健康变化提供了有价值的数据.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.1K
Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
The Thyroid Gland
3.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.4K
Regulation of Hormone Secretion
3.0K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
Humoral...
3.0K
Longitudinal Research
11.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.8K

