使用egs_brachychy治疗的蒙特卡洛剂量计算的图形用户界面
Narjes Moghadam1, Fatemeh Akbari1, Shannon Jarvis1
1Carleton Laboratory for Radiotherapy Physics, Department of Physics, Carleton University, Ottawa, Ontario, Canada.
Medical physics
|March 8, 2025
概括
这项研究介绍了eb_gui,这是一个开源工具,可以使用蒙特卡洛模拟来准确计算支臂治疗剂量. 它使患者特定的治疗规划成为可能,提高了放射治疗的精度.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 计算成像技术的成像
背景情况:
- 先进的支臂疗法需要比传统的TG43方法更精确的剂量计算.
- 目前的蒙特卡洛 (MC) 代码缺乏有效的临床数据集成,以实现符合TG186规划.
- 有限的可访问的MC工具阻碍了采用复杂的剂量计算算法.
研究的目的:
- 呈现和验证eb_gui,一个用于将DICOM数据与egs_brachyMC代码集成的图形用户界面.
- 为了便于快速,基于模型的剂量计算,用于手臂治疗应用.
- 为了弥合临床数据和高级MC模拟之间的差距,为TG186推.
主要方法:
- 使用C++和Qt5框架开发eb_gui以实现用户友好的集成.
- 通过五个基准测试场景验证eb_gui,包括WG-MBDC测试案例.
- 使用局部/全球剂量差异,剂量组图和HDR乳腺和LDR前列腺病例的比例图来评估准确性.
主要成果:
- 在测试案例中,超过95%的voxels显示<±0.40%的局部剂量差异和<±0.02%的全球差异.
- HDR乳腺病例显示>95%的全球差异比率在[-0.31%,+0.39%]范围内.
- LDR前列腺病例模拟证实了eb_gui的全面能力和高精度.
结论:
- eb_gui成功地将临床数据与egs_brachy集成为符合TG186的患者特定剂量评估.
- 开源版本促进了先进的MC剂量计算的广泛临床采用.
- 这种工具提高了个性化支臂疗法治疗的准确性和效率.
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