短期环境NO2与2型糖尿病门诊访问之间的关联:在多个城市的时间序列研究,中国
Huilan Lu1, Hongran Ma2, Jiyuan Dong2
1School of Nursing, Lanzhou University, Lanzhou, 730000, PR China. leihl@lzu.edu.cn.
International journal of biometeorology
|March 8, 2025
概括
对二氧化 (NO2) 的暴露与中国三座城市的2型糖尿病 (T2DM) 门诊诊次数增加有关. 二氧化的有害影响在男性,年轻人以及在寒冷的季节更为明显.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 慢性疾病研究 慢性疾病研究
背景情况:
- 2型糖尿病 (T2DM) 是一种普遍的慢性疾病,对健康和经济产生重大影响.
- 将二氧化 (NO2) 暴露与T2DM恶化相关的证据有限.
- 了解T2DM的环境风险因素对于公共卫生至关重要.
研究的目的:
- 调查环境二氧化 (NO2) 水平与T2DM每日门诊访问之间的关联.
- 评估NO2暴露对T2DM的滞后效应.
- 探索根据性别,年龄和季节的潜在效果修改.
主要方法:
- 利用了2018-2020年中国丁,天水和龙南T2DM门诊患者,空气污染物 (包括NO2) 和气象因素的每日数据.
- 采用近似波桑回归的通用增量模型 (GAM).
- 应用分布式滞后非线性模型 (DLNM) 来分析关联和滞后效应,根据性别,年龄和季节进行分层分析.
主要成果:
- 在这三个城市中,在NO2暴露和每日增加的T2DM门诊访问之间发现了显著的积极关联.
- 最大的相对风险 (RR) 观察到的是累积滞后日 (例如,lag05,lag07).
- 分层分析表明,男性,65岁以下的个人和寒冷的季节经历了NO2暴露的更大的不良影响.
结论:
- 环境NO2暴露与在研究中中国城市T2DM门诊诊次数增加有关.
- 这些发现突显了NO2在T2DM病原和恶化中的潜在作用.
- 需要进一步的研究来阐明在中国T2DM中NO2暴露的机制和影响.
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