相关实验视频

Updated: May 23, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

针对性纳米粒子输送系统用于与瘤相关的巨细胞重编程,以增强TNBC治疗

Xiaoshen Dong¹, Xiaoou Wang², Xinyu Zheng^1,3

¹Department of Surgical Oncology, Breast Surgery, General Surgery, The First Hospital of China Medical University, 155 North Nanjing St, Shenyang, 110001, China.

Cell biology and toxicology

|March 8, 2025

概括

我们开发了向纳米颗粒 (M2pep-Cs-Cur NPs),可以抑制三阴性乳腺癌 (TNBC) 的生长和入侵. 这些纳米粒子通过逆转M2极化瘤相关巨细胞 (TAMs) 来提高免疫治疗的有效性.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

三阴性乳腺癌 (TNBC) 的治疗选择有限,预后不佳.
分离到M2状态的瘤相关巨细胞 (TAMs) 在瘤微环境 (TME) 中促进瘤生长和免疫逃避.

研究的目的:

开发和评估M2pep-Cs-CurNP,一个针对TNBC治疗的向纳米粒子系统.
研究这些纳米粒子的潜力,以逆转M2 TAM两极分化和克服免疫疗法耐药性.

主要方法:

使用素 (Cs) 作为载体,素 (Cur) 作为治疗剂和M2向的M2pep-Cs-CurNP的配方.
在体外和体内评估NP在抑制TNBC细胞增殖和入侵方面的疗效.
评估NP对瘤对抗PD-L1免疫疗法的反应的影响.
生物信息学分析以阐明Cur在调节TAM极化中的机制.

主要成果:

M2pep-Cs-Cur NPs显著抑制了TNBC细胞的增殖和入侵,约为70%.
这些纳米颗粒增强了瘤对抗PD-L1治疗的反应,在体内改善了约50%的生存率.
生物信息学分析表明,黄素通过COX-2等关键基因调节TAM极化.

结论:

M2pep-Cs-Cur NPs代表了TNBC的一个有希望的向治疗策略.
这些纳米粒子可以逆转M2 TAM极化,提供一种潜在的方法来克服TNBC的免疫疗法耐药性.

关键词:

在COX-2中,COX-2是最常见的.库尔库明是一种黄素.免疫疗法耐药性免疫疗法耐药性纳米颗粒纳米颗粒重编程重编程是一种重编程.三阴性乳腺癌是三阴性乳腺癌.与瘤相关的巨细胞.

更多相关视频

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...