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急性和慢性胰腺炎患者的预期寿命降低
Satish Munigala1,2, Divya S Subramaniam3,4, Dipti P Subramaniam3
1College for Public Health and Social Justice, Saint Louis University, HCOR Office St. Louis, 3545 Lafayette Ave, Salus Center 4th Floor, Saint Louis, MO, 63104, USA. satish.munigala@slu.edu.
Digestive diseases and sciences
|March 8, 2025
概括
与一般人群相比,患有急性 (AP) 和慢性胰腺炎 (CP) 的患者的预期寿命显著缩短,死亡风险增加. 大多数死亡是由于非胃肠道原因,突出显示胰腺炎的全身影响.
科学领域:
- 胃肠病学和肝病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在美国,关于急性胰腺炎 (AP) 和慢性胰腺炎 (CP) 的预期寿命和死亡率的基于人口的数据有限.
- 胰腺炎显著影响患者的生存,需要进一步调查死亡率和死亡原因.
研究的目的:
- 评估诊断为AP和CP的患者的预期寿命,死亡率和死亡原因.
- 为了比较AP和CP患者的结果与一般人群中的对照组.
主要方法:
- 利用退伍军人管理局数据库 (1999-2015) 用ICD-9代码识别AP和CP患者.
- 通过考克斯比例危险模型比较胰腺炎患者和非胰腺炎对照者的预期寿命 (使用死亡年龄) 和死亡率.
主要成果:
- 与对照组 (81年) 相比,AP和CP患者的预期寿命显著降低 (分别为69岁和71岁).
- 与对照组相比,AP (aHR 1.61) 和CP (aHR 1.64) 患者的死亡风险明显高于对照组.
- AP和CP患者的主要死亡原因包括循环疾病,瘤和呼吸系统疾病,超过42%的胰腺炎患者在随访期间死亡.
结论:
- 急性和慢性胰腺炎与寿命缩短和死亡风险增加有关,这强调了它们的临床意义.
- 虽然来自胃肠道疾病的死亡人数较高,但大多数AP和CP患者的死亡人数源自非胃肠道原因.
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