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在动物模型中,α-Klotho与Ganoderma lucidum的抗衰老作用的关联

Xiaojing Liu¹, Jiamin Zhao¹, Jia Liu¹

¹State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, 300071, China.

Journal of ethnopharmacology

|March 8, 2025

概括

甘白斑子粉通过增加α-Klotho水平来延长寿命并改善老龄化模型的健康. 这项研究揭示了其作为天然抗衰老干预措施的潜力.

科学领域:

老年学和长寿研究研究.
传统中国医学和药理学
分子生物学和衰老机制

背景情况:

衰老是一个普遍的过程,涉及多个器官的衰退.
光 (G. lucidum) 传统上以其抗衰老特性而闻名.
基於G. lucidum抗衰老作用的機制尚未完全理解.

研究的目的:

为了研究G. lucidum sporoderm-broken spore powder (Gl-SBSP) 的抗衰老作用. 为了研究G. lucidum sporoderm-broken spore powder (Gl-SBSP) 的抗衰老作用. 为了研究G. lucidum sporoderm-broken spore powder (Gl-SBSP) 的抗衰老作用.
阐明G. lucidum抗衰老作用的潜在分子机制.

主要方法:

在Caenorhabditis elegans和小鼠模型中评估了Gl-SBSP对寿命和衰老的影响 (自然,D-银糖,辐射诱导的衰老).
评估了生理参数,氧化应激 (ROS),脂素和组织完整性.
量化阿尔法-克洛托 (α-Klotho) 含量使用西方污染和免疫组织化学.

主要成果:

Gl-SBSP显著延长了C. elegans的寿命,并改善了健康指标.
Gl-SBSP缓解了老化相关的老鼠多个器官的衰退.
Gl-SBSP增加了脏,血清和尿液中的跨膜和可溶性α-Klotho水平.

结论:

这项研究为动物模型中G. lucidum与α-Klotho相关的抗衰老作用提供了第一个证据.
G. lucidum显示出作为一种天然的抗衰老干预措施的潜力.
这些发现突出了α-Klotho在调解G. lucidum的益处方面的作用.

关键词:

衰老的衰老衰老的衰老老化的老鼠模型.功能性衰退功能性衰退这种植物叫做Ganoderma lucidum.α - 克洛托霍 (Klotho) 是一种

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