使用有针对性的元基因组方法研究影响人类暴露于抗生素耐药细菌的景观规模变量
A F C Leonard1, S L Higgins1, M Hui2
1European Centre for Environment and Human Health, University of Exeter Medical School, Penryn, UK.
Environmental pollution (Barking, Essex : 1987)
|March 8, 2025
概括
在香港的抗生素耐药细菌 (ARB).
科学领域:
- 环境微生物学环境微生物学
- 公共卫生 公共卫生
- 基因组学就是基因组学.
背景情况:
- 暴露在抗生素耐药细菌 (ARB) 的沿海水域增加了肠道殖民的风险.
- 了解ARB在休水域的传播对于公共卫生至关重要.
研究的目的:
- 为了确定影响香港沿海水域ARB传播的景观规模因素.
- 为了量化游泳者在这些水域暴露于ARB的数量.
主要方法:
- 在12个地点对休用水进行大肠杆菌 (E. coli) 的抽样.
- 在可活的大肠杆菌中量化抗生素耐药性基因 (ARG) 的元基因组分析.
- 建模环境变量和人类使用数据,以评估ARB暴露风险.
主要成果:
- 在西部海上检测到高水平的ARG和耐美罗的细菌.
- 表明珍珠河对水质和ARB水平的影响.
- 平均每种大肠杆菌发现了6.09个ARG,超过116万次暴露事件.
结论:
- 娱乐用水使用带来了暴露于殖民性ARB的重大风险.
- 香港西部的海显示了更高的ARB水平,可能是由于珍珠河.
- 尽管废水处理得到了改进,但沿海水域的ARB暴露仍然令人担忧.
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