喘妇女的生育结果:丹麦全国性队列研究
Anne Vejen Hansen1, Kjell E J Håkansson1, Anders P Mikkelsen2
1Respiratory Research Unit Hvidovre, Department of Respiratory Medicine, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
患有喘的女性面临更高的需要生育治疗的风险,特别是更严重的喘. 然而,喘似乎没有影响实现活产的数量.
科学领域:
- 生殖医学 生殖医学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 喘在生育年龄的女性中很普遍.
- 以前的研究表明,喘与生育能力下降之间存在联系,包括更长的受孕时间.
研究的目的:
- 为了比较喘妇女与没有喘妇女的生育治疗率.
- 评估喘严重程度对生育治疗需求的影响.
主要方法:
- 从18岁到2017年,跟踪了一大批丹麦妇女 (1976-1999年出生) 的情况.
- 喘诊断是基于对喘药物的重复处方.
- 严重程度使用全球喘倡议 (GINA) 准则进行分类.
- 使用了因年龄,日历年份和教育而调整的考克斯回归分析.
主要成果:
- 超过765,000名妇女被跟踪了平均10.8年.
- 患有喘的妇女的胎儿损失率略高 (17.0%对15.8%) 和生育治疗 (5.6%对5.0%).
- 患有喘的女性需要接受生育治疗的风险显著增加 (HR:1.10).
- 更高的喘严重程度 (GINA 4-5级) 和频繁的恶化 (≥3) 进一步提高了受孕治疗的风险.
结论:
- 患有喘的女性表现出更多地利用生育治疗.
- 这种增加对生育治疗的需求与喘严重程度和恶化频率有关.
- 然而,喘似乎并没有对活产儿总数产生负面影响.
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