特里亚托马感染者的Trypanosoma cruzi和微生物组之间的相互作用:对宿主的免疫反应的影响
Paula Ragone1, Cecilia Parodi1, Nicolás Tomasini1
1Instituto de Patología Experimental - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Universidad Nacional de Salta (UNSa).
Acta tropica
|March 8, 2025
概括
载体便影响Trypanosoma cruzi感染的动态. 暴露在感染便中的小鼠表现出免疫反应的改变和寄生虫负载的减少,这表明肠道微生物群在查加斯病进展中的作用.
科学领域:
- 寄生虫学的寄生虫学
- 免疫学 免疫学 免疫学
- 微生物组学 微生物组学
背景情况:
- 感染Trypanosoma cruzi的动态受宿主,载体和寄生虫因素的影响.
- 大多数研究使用了虫寄生虫培养物,忽略了载体便成分.
- 这项研究调查了Triatoma infestans便对小鼠T. cruzi感染的影响.
研究的目的:
- 分析T. cruzi与载体便相互作用后的免疫反应和寄生虫负载.
- 为了比较免疫反应和感染便接种的小鼠与培养衍生型形虫之间的寄生虫负担.
- 调查载体便微生物群在调节夏加斯病中的作用.
主要方法:
- 使用16S rRNA基因测序对受感染和未受感染的Triatoma infestans便进行元基因组学分析.
- 鼠模型 (C57BL/6J) 接种了T. cruzi感染的便或培养衍生型形虫.
- 预炎性 (IFN-ɣ,TNF-α) 和调控性 (IL-10) 细胞因子的量化.
- 对抗T. cruziIgG,IgG1和IgG2c抗体水平的分析.
- 测量血液和肌肉寄生虫负载.
主要成果:
- 微生物群分析显示,感染便中的Arsenophonus和未感染便中的Enterococcus.
- 用受感染便接种的小鼠表现出较低的促炎细胞因子 (IFN-ɣ,TNF-α) 和较高的IL-10.
- 感染便组的IgG1和IgG2c水平降低表明了平衡的Th1/Th2反应.
- 在被感染便接种的小鼠中观察到明显较低的血液和肌肉寄生虫负载.
- 这些结果表明,有调节性免疫反应,并减少了寄生虫传播.
结论:
- 载体便微生物群的组成会影响宿主对T. cruzi. 的免疫反应.
- 感染便可以通过调节免疫反应来限制炎症和寄生虫的传播.
- 这些发现凸显了考虑到与载体相关的因素在查加斯病的发病过程中的重要性.
- 载体肠道微生物群可能是治疗或预防策略的潜在目标.
相关概念视频
Factors Affecting the Risk of Infection
14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
Microbial Interactions: Parasitism
108
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
108
Introduction to the Human Microbiota
209
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
209
Colonisation of Pathogens
77
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
77


