蛋白酶调节瘤免疫细胞共生的过程
Lizhi Pang1, Yuyun Huang1, Jean Huang-Gao1
1Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Trends in cancer
|March 8, 2025
概括
瘤微环境 (TME) 中的蛋白酶调节癌细胞和免疫细胞的相互作用,影响瘤进展和免疫疗法耐药性. 准这些蛋白酶活动为增强癌症治疗提供了新的策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 蛋白酶传统上会降解细胞外基质 (ECM),促进瘤生长.
- 蛋白酶 (caspases,cathepsins,USPs) 在调节瘤微环境 (TME) 免疫信号中的新兴作用.
- 由蛋白酶介导的瘤免疫细胞共生是癌症进展和免疫疗法耐药性的关键.
研究的目的:
- 审查最近关于瘤和免疫细胞之间的蛋白酶介导交叉通话的见解.
- 为了强调这种共生对瘤进展和免疫抑制的影响.
- 讨论针对癌症治疗中的蛋白酶介导相互作用的治疗策略.
主要方法:
- 关于癌症免疫学中蛋白酶的当前研究的文献综述.
- 分析TME中的蛋白酶功能及其对免疫细胞的影响.
- 综合发现,以确定治疗机会.
主要成果:
- 蛋白酶积极塑造TME,影响免疫细胞功能和瘤进展.
- 特定的蛋白酶 (caspases,cathepsins,USPs) 被确定为瘤免疫交叉的关键调节者.
- 蛋白酶介导的相互作用有助于免疫逃避和对免疫疗法的抵抗.
结论:
- 蛋白酶介导的瘤免疫细胞相互作用是癌症进展和免疫抑制的关键驱动因素.
- 针对这些蛋白酶活动可以破坏瘤免疫共生.
- 利用蛋白酶功能为"冷"瘤对免疫疗法,包括免疫检查点抑制剂 (ICI) 的敏感化提供了一个有希望的途径.
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