在Prevotella copri中产生的5-aminopentanoic酸促进了儿科代谢功能障碍相关的脂肪性肝病
Qing-Yang Xu1, Tian-Yi Ren1, Yong-Chang Zhou2
1Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
概括
普雷沃特拉·科普里 (Prevotella copri) 的扩张驱动了儿科代谢功能障碍相关的脂肪性肝病 (MASLD),通过产生5-氨基酸 (5-AVA). 这种代谢物会恶化肝硬化症,表明P.copri和5-AVA是儿科MASLD的潜在治疗点.
科学领域:
- 微生物学 微生物学
- 肝病学 肝病学是一种肝病学.
- 儿科胃肠病学 儿科胃肠病学
背景情况:
- 新出现的证据将Prevotella copri (P. copri) 扩张与儿童代谢功能障碍相关的脂肪性肝病 (MASLD) 的严重程度增加联系在一起.
- 在儿科MASLD中P.copri的确切作用和分子机制仍需要阐明.
研究的目的:
- 调查P.copri在儿科MASLD中的致病作用.
- 确定P.copri通过哪些分子机制导致肝硬化.
主要方法:
- 给C57BL/6 J小鼠吃高脂肪饮食 (HFD) 并口服P.copri5周.
- 评估了MASLD特征和肠道微生物群. 未定位的代谢组确定了P.copri衍生代谢物,这些代谢物在体外进行了测试.
主要成果:
- 在HFD养的小鼠中,P. copri的使用加剧了肝硬化症,并上调了炎症和纤维化基因.
- P. copri改变了肠道微生物群的组成,并显著丰富了5-aminopentanoic 酸 (5-AVA).
- 在体外,5-AVA通过促进脂质生成和脂肪酸吸收,加剧了肝细胞中的脂质积累,同时损害了VLDL出口.
结论:
- 在幼年小鼠中,P. copri通过其代谢物5-AVA.促进肝脏肥胖症.
- 这些发现突出了P.copri和5-AVA作为儿科MASLD管理的潜在治疗点.
相关概念视频
01:24Overview of Lipid Metabolism
914
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
914
01:28Overview of Fatty Acid Metabolism
30.1K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.1K
01:27Protein Import into the Peroxisomes
3.3K
Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
3.3K