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Updated: May 23, 2025

Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype
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瘤原和微环境信号驱动青少年骨髓单细胞白血病中细胞类型特异性亡耐药性

Naile Koleci1,2,3,4, Ying Wu1,2, Niels Anton Wehner1

  • 1Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Cell death & disease
|March 8, 2025
PubMed
概括

青少年骨髓单细胞白血病 (JMML) 涉及RAS通路的激活,影响细胞存活. 准BCL-XL对髓状细胞死亡有希望,但不能完全解决体内细胞的增殖.

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When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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