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骨肌肉线粒体功能障碍与老年小鼠的Gdf15表达和循环GDF15水平增加有关

J Chen1, J Kastroll1, F M Bello1

  • 1Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST W1060, Pittsburgh, PA, 15213, USA.

Scientific reports
|March 8, 2025
PubMed
概括

增长差异化因子-15 (GDF15) 的水平随着年龄的增长而上升. 在老年小鼠中,骨肌GDF15表达增加,与线粒体功能受损有关,这表明肌肉是关键来源.

关键词:
衰老的衰老 衰老的衰老能源支出 能源支出胰岛素耐药性 胰岛素耐药性是一种综合应激反应综合应激反应呼吸计呼吸计呼吸计呼吸计

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