饮食酸负荷与前列腺癌的几率之间的关联:一个病例对照研究
Sanaz Mehranfar1, Yahya Jalilpiran1,2, Haleh Rahimi3
1Department of community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Journal of health, population, and nutrition
|March 8, 2025
概括
较高的食酸负荷 (DAL) 与前列腺癌 (PC) 风险增加有关. 这表明饮食可能在PC发育中起作用,需要进一步调查.
科学领域:
- 营养科学 营养科学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 关于饮食中的酸负荷 (DAL) 与癌症风险之间的联系存在相互矛盾的证据.
- 调查DAL与前列腺癌 (PC) 的关联对公共卫生至关重要.
- 了解影响PC的饮食因素可以帮助预防策略.
研究的目的:
- 为了检查饮食酸负荷 (DAL) 和患前列腺癌 (PC) 的几率之间的关联.
- 评估潜在的酸负荷 (PRAL) 和内源性净酸产量 (NEAP) 在PC风险中的作用.
- 为伊朗人口提供有关饮食可修改的PC风险因素的见解.
主要方法:
- 一项基于医院的病例控制研究,涉及60名PC患者和60名对照.
- 评估饮食摄入量使用160项的半定量食品频率调查问卷 (FFQ).
- DAL通过PRAL和NEAP计算;用于确定赔率比率 (ORs) 的多变量逻辑回归.
主要成果:
- 在原始和调整模型中,PRAL和NEAP都显示出与PC赔率增加的显著关联.
- 经过对混因子进行调整后,较高的PRAL (OR=3.42) 和NEAP (OR=3.88) 仍然与PC风险增加有关.
- 这些发现表明饮食对前列腺癌发展的潜在贡献.
结论:
- 饮食中的酸负荷 (DAL) 可能与前列腺癌 (PC) 的风险增加有关.
- 需要进一步的大规模前性研究来证实这些发现.
- 针对酸性负载的饮食干预措施可以用于PC预防.
相关概念视频
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
Peptic Ulcer Disease I: Introduction
114
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
114
Hazard Ratio
73
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
73
Stomach pH Regulation
5.9K
The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
5.9K
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
333
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
333
Relative Risk
104
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
104


