在缺血性中风患者中糖尿病状况,持续时间和痴呆风险
Jonguk Kim1,2, Kyung-Do Han3, Jeong-Yoon Lee4
1Departments of Neurology, Inha University Hospital, Incheon, Korea.
Alzheimer's research & therapy
|March 8, 2025
概括
较长时间的2型糖尿病 (T2DM) 显著增加了中风幸存者的痴呆风险. 超过五年的确定的T2DM显示,患痴呆症的风险增加了46.7%,包括阿尔茨海默氏症和血管痴呆症.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2DM) 持续时间和中风后患者的新发性痴呆风险之间的关系尚不清楚.
- 了解这种关联对于中风幸存者的痴呆症预防策略至关重要.
研究的目的:
- 调查T2DM持续时间与中风后人口中发展痴呆症的风险之间的关联.
- 根据T2DM持续时间量化所有原因痴呆症,阿尔茨海默病 (AD) 和血管痴呆症 (VaD) 的增加风险.
主要方法:
- 使用韩国国家医疗保险数据库进行的一项大型队列研究.
- 包括118,790名没有先前痴呆症诊断的中风幸存者.
- 糖尿病状况分类为正常血糖,禁食葡萄糖 (IFG) 损害,新诊断的T2DM和持续时间<5年和≥5年的T2DM.
主要成果:
- 16.7%的参与者在平均7.3年的随访期间患上了痴呆症.
- 与正常血糖相比,T2DM持续时间<5年与痴呆症风险增加26.7%有关.
- T2DM持续时间≥5年显示,所有原因痴呆的风险增加了46.7% (aHR1.466),AD风险增加 (aHR1.434) 和VaD风险增加 (aHR1.514).
结论:
- 在中风后的人群中,T2DM延长的持续时间与所有原因痴呆症,AD和VaD的风险增加显著相关.
- 这些发现凸显了在中风幸存者中积极预防痴呆症的重要性,特别是那些长期患有T2DM的人.
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