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使用针对CD19的免疫调节来消灭AAV中和抗体

Bhavya S Doshi1, Caroline A Markmann2, Noelle Novak3

  • 1Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Raymond G. Perelman Center for Cellular and Molecular Therapy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA.

Molecular therapy : the journal of the American Society of Gene Therapy
|March 9, 2025
PubMed
概括

对腺相关病毒 (AAV) 的中和抗体阻碍了基因疗法. CD19 CAR-T细胞疗法在小鼠中有效地消除了这些抗体,使得AAV的成功再注射和转基因表达成为可能.

关键词:
在AAV基因疗法中,AAV基因疗法在CART-T中,我们可以使用CAR-T.免疫性 免疫性 免疫性中和抗体中和抗体.重新管理的重复管理

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