在克罗恩病的肠切除中,扩展与有限的半肠切除:元分析和系统性审查
B F Pompeu1,2, P Marcolin3, F I L C B Marques4
1Department of Colorectal Surgery, Heliopolis Hospital, Rua Santo Antônio, 50 - Centro, São Caetano do Sul, São Paulo, Brazil. bernardo.pompeu@online.uscs.edu.br.
Techniques in coloproctology
|March 9, 2025
概括
延长间肠切除 (EME) 与有限间肠切除 (LME) 相比,在克罗恩病 (CD) 患者中显著减少手术复发. 这种方法不会增加术后并发症或内镜复发率.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 炎症性肠道疾病 炎症性肠病
背景情况:
- 关于延长间膜切除 (EME) 与有限间膜切除 (LME) 对于克罗恩氏病 (CD) 肠切除的疗效存在争论.
- 一些证据表明,与LME相比,EME可能会降低外科复发率.
研究的目的:
- 系统地审查和分析经手术后的并发症,手术复发和内镜复发在经过EME和LME的CD患者中.
主要方法:
- 在 MEDLINE,Cochrane,CENTRAL,Scopus 和 Web of Science 数据库中搜索到 2024 年 4 月.
- 使用随机效应模型的95%置信区间 (CI) 的聚合赔率比率 (OR).
- 使用科克兰的Q测试和I2统计数据评估异质性.
主要成果:
- 包括1个RCT和5个观察性研究 (4498名患者:1059名EME,3439名LME).
- 经过外科手术,EME的复发率显著降低 (5%与15%相比;OR 0.31;p=0.021).
- 对于整体并发症,特定并发症 (如泄漏,感染),重新手术,再入院,内镜复发,手术时间或住院没有发现显著差异.
结论:
- 延长间膜切除 (EME) 与克罗恩病手术复发的显著减少有关.
- 与有限间膜切除 (LME) 相比,EME不会增加术后并发症或内镜复发率.
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