核心针活检对HER2-低早期乳腺癌的可靠性
C M Ciniselli1, P Verderio2, V Duroni1
1Bioinformatics and Biostatistics Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133, Milan, Italy.
概括
核心针活检 (CNB) 显示了对HER2阳性乳腺癌的高度同意,但对HER2低状态的公平同意. 对于最初被归类为HER2-0的大型瘤,由于新的HER2-低治疗方法,建议重新测试.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 遗传学 遗传学 是一个
背景情况:
- 核心针活检 (CNB) 对HER2阳性乳腺癌是可靠的.
- 有限的数据存在于HER2-低乳腺癌的CNB和手术样本之间的一致性.
研究的目的:
- 评估早期乳腺癌中CNB和手术样本之间的HER2状态的一致性.
- 为了确定影响异调的因素,特别是在HER2低的病例中.
主要方法:
- 分析了一系列连续的776名以前没有接受过治疗的乳腺癌早期患者.
- 使用未加权的科恩卡帕统计 (Kc) 评估一致性.
- 后勤回归模型评估了一致性和临床病理特征之间的关联.
主要成果:
- 对于HER2阳性状态 (95%) 观察到高一致性 (Kc=0.86).
- 在HER2-0与HER2-低分类之间发现了公平协议 (Kc=0.22),在两个方向上都有显著的重新分类.
- 瘤大小>2厘米与错误分类的风险增加了一倍.
结论:
- 重新检测HER2状态至关重要,特别是在最初被诊断为HER2-0.的大型瘤中.
- 准确的HER2-低分类对于指导使用新疗法 (如抗体-药物联体) 的治疗至关重要.
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