维生素D与痛风患者的死亡风险之间的关联
Xinyu Fang1,2, Jie Zhang2,3, Zixing Zhang1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui 230032, China.
Journal of public health (Oxford, England)
|March 9, 2025
概括
较高的维生素D水平与痛风患者的死亡率降低有关. 维持足够的25-氧维生素D (25(OH) D可以降低所有原因和心血管死亡风险.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 在痛风患者中,25-氧维生素D[25(OH) D]水平与死亡率之间的关系尚未得到充分证实.
- 痛风患者可能有各种各样的全因死亡率 (ACM) 和心血管死亡率 (CVM) 的风险,受维生素D状态的影响.
研究的目的:
- 在痛风患者中研究血清25(OH) D水平与ACM和CVM之间的关联.
- 探索这种人群中维生素D状况和死亡率结果之间的潜在因果关系.
主要方法:
- 分析了来自7337名痛风患者的英国生物库数据,并将其与国家死亡登记信息联系起来.
- 测量基线血清25(OH) D水平,并应用Cox比例危险回归和孟德尔随机化 (MR) 分析.
- 评估非线性关系和因果推断25~OH) D和死亡率之间的关系.
主要成果:
- 在血清25(OH) D水平和ACM和CVM之间观察到一个L形的反向关联,其值为45nmol/L.
- 痛风患者的25(OH) D水平≥45nmol/L的ACM风险显著降低 (HR 0.72).
- 非线性MR支持足够的25-OH-D (≥50nmol/L) 和降低的ACM之间的因果关系;更高的水平也可能减轻了CVM.
结论:
- 在患有痛风的个体中,血清25(OH) D水平升高与全因和心血管死亡风险降低有关.
- 达到足够的25-基维生素D水平可能是改善痛风患者生存结果的可修改因素.
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