晚期非小细胞肺癌存活率中的性别差异:丹麦全国性研究
Matilde Grupe Frost1, Kristoffer Jarlov Jensen2, Espen Jimenez-Solem1
1Department of Clinical Pharmacology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; Copenhagen Phase IV Unit (Phase4CPH), Department of Clinical Pharmacology and Center for Clinical Research and Prevention, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
Lung cancer (Amsterdam, Netherlands)
|March 9, 2025
概括
患有晚期非小细胞肺癌 (NSCLC) 的女性比男性存活时间更长,即使考虑到已知的因素. 这凸显了需要将性别视为NSCLC研究和治疗中的关键变量.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 临床试验 临床试验
背景情况:
- 癌症在历史上表现出性二态.
- 性别对患者和瘤特征的影响,以及晚期非小细胞肺癌 (NSCLC) 的存活率尚未得到充分研究,特别是在新疗法中.
研究的目的:
- 为了研究患者和瘤特征,治疗和晚期非小细胞肺癌 (NSCLC) 的整体存活率 (OS) 的基于性别的差异.
- 在免疫检查点抑制剂和向治疗时代,探索性与结果的关联.
主要方法:
- 使用丹麦全国性注册 (2017-2023) 的观察性研究,包括14635名患有高级NSCLC的成年人.
- 在人口统计,社会,社会经济,患者和瘤特征 (PD-L1,驱动突变) 中,女性与男性的比较.
- 考克斯回归和倾向得分匹配分析了从诊断和治疗开始的整体存活率 (OS),按阶段,组织学,PD-L1和治疗分层.
主要成果:
- 与男性相比,女性的总生存时间 (OS) 显著更长,无论是原始还是调整后.
- 诊断后的中位数生存期为女性8.8个月,男性7.0个月;从治疗开始,为14.1个月,男性10.9个月.
- 分层分析证实了所有子组中女性的良好或可比结果.
结论:
- 患有晚期NSCLC的女性比男性存活时间更长,独立于之前识别的因素.
- 未确定的性别差异可能会导致生存差异,这可能会产生潜在的临床影响.
- 承认性别作为一个关键变量对于NSCLC瘤学试验,研究和临床实践至关重要.
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