氨酸补充剂可缓解喘气道炎症,这种炎症因HOCl暴露而加剧
Yingjun Chen1, Shiting Yi1, Qian Wang1
1Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Journal of hazardous materials
|March 9, 2025
概括
暴露于低酸 (HOCl) 的环境会通过改变肠道细菌和新陈代谢,使喘气道炎症在小鼠中恶化. 氨酸补充可能提供一种治疗方法来减轻这些影响.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 环境污染物与喘的发展和进展有关.
- 酸 (HOCl) 是一种常见的消毒剂,其在喘相关的呼吸道炎症中的特定作用尚不清楚.
研究的目的:
- 研究饮用水中HOCl的早期和周产期暴露对小鼠喘呼吸道炎症的影响.
- 探索HOCl暴露对喘小鼠肠道微生物群组成和便代谢学的影响.
- 评估 taurine 在缓解 HOCl 诱导的喘恶化中的治疗潜力.
主要方法:
- 用小鼠模型来评估HOCl在生命早期和围产期饮用水中的作用.
- 进行了肠道微生物群测序和便代谢学,以分析微生物多样性和代谢途径的变化.
- 治疗小鼠的氨酸,一个已知的HOCl中和剂,以评估其保护作用.
主要成果:
- 早期和围产期的HOCl暴露加剧了喘小鼠的呼吸道炎症,并促进了后代的炎症.
- 暴露于HOCl减少了肠道微生物群的多样性,减少了像Lactobacillus这样的有益细菌,增加了机会性细菌.
- 暴露于HOCl显著增强了阿拉基酸代谢途径,在细菌属和代谢物水平之间观察到相关性.
- 氨酸治疗显著缓解了由HOCl暴露加剧的喘气道炎症.
结论:
- 暴露于HOCl会通过肠道微生物群失调和改变代谢途径加剧喘气道炎症.
- 氨酸补充证明了作为一种治疗策略的潜力,以抵消HOCl诱导的喘恶化.
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