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开发和初步验证基于回归的标准化变化得分作为过渡性认知衰退的衡量标准
Andrew M Kiselica1, Alyssa N Kaser2, Troy A Webber3
1Division of Neuropsychology, Baylor Scott and White Health, Temple, TX, USA.
概括
本研究介绍了基于回归 (SRB) 的标准化变化指数,用于追踪衰老研究中的认知衰退. 这些经过验证的工具有助于识别老年人的过渡性认知变化.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 心理测量 心理测量 心理测量
背景情况:
- 识别过渡性认知衰退在阿尔茨海默氏症和衰老研究中至关重要.
- 基于回归的标准化变化指数 (SRB) 提供了一种量化连续认知评估变化的方法.
研究的目的:
- 为统一数据集3.0神经心理电池开发和初步验证SRB变化指数.
- 为解释认知完整的老年人SRB变化指数提供基准速率数据.
主要方法:
- 利用了来自1341位认知完整的老年人的数据,并从国家阿尔茨海默氏症协调中心数据库中进行了连续评估 (0.5-2年).
- 计算和验证了半个样本的SRB变化得分,评估了不同z-score切割点的基本下降率.
- 检查了SRB指数和与临床痴呆症评级总和 (CDR-SB) 的并发关联之间的融合关联.
主要成果:
- SRB方程显著预测了认知变量.
- 至少有一个显著的SRB下降的基准率在28.91%至64.90%之间.
- SRB指数显示了预期的相互积极关联,CDR-SB损失与三个SRB指数的下降相关.
结论:
- 在大样本中实现了SRB指数的初步验证.
- 介绍了用于计算SRB值的用户友好的工具,有助于解释认知变化.
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