可吸入的pH响应的核心外纳米载体,带有PEGylated chitosan/alginate层层涂层,用于在肺癌治疗中顺序释放药物
Mariam Hossam Eldin1, Kholoud K Arafa1, Osman Gamal1
1Nanomedicine Laboratories, Center for Materials Science, Zewail City of Science and Technology, 6th of October City, 12578 Giza, Egypt.
International journal of biological macromolecules
|March 9, 2025
概括
一种新的可吸入纳米载体系统可为肺癌治疗顺序提供凝胺和多塞,提高疗效和安全性. 这种有针对性的方法增强了药物输送到肺部,减少了全身毒性.
科学领域:
- 纳米技术用于药物输送.
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
背景情况:
- 由于高死亡率,肺癌需要有效的治疗方法.
- 目前的吉姆西塔 (GMC) 和多塞塔克塞尔 (DTX) 化疗药物治疗面临着包括全身毒性和不良药理学在内的局限性.
- 需要改进药物输送系统,以提高治疗结果和患者安全.
研究的目的:
- 开发一种可吸入的新型纳米载体 (NC),用于连续释放凝胺和多塞.
- 评估开发的NC的物理化学性质,气溶化行为,体外疗效和体外安全性.
- 评估NC在向性肺癌治疗中的潜力.
主要方法:
- 核心外纳米载体的制造:核中装有多塞塔克塞尔 (DTX) 的氨基化介质 (MSNs),涂有酸盐 (Alg),并进一步封装在装有凝心素 (GMC) 的PEGylated-chitosan (PEG-CS) 中.
- 综合的物理化学表征 (大小,表面电荷,药物捕获效率).
- 在体外释放药物的研究,在体外对A549肺癌细胞的细胞毒性测定,使用下一代冲击器 (NGI) 的气溶化研究,以及体内生物分布和组织病理学研究.
主要成果:
- 成功合成了具有150nm大小和+32mV表面电荷的球形核心外NC.
- 实现了高的药物捕获效率 (DTX为75.2%,GMC为32.5%) 和连续的药物释放.
- 证明了有效的肺沉积,有利的气溶化,增强的体外细胞毒性,体内显著的肺积累,以及良好的安全性.
结论:
- 开发的可吸入纳米载体系统使得gemcitabine和docetaxel的顺序递送能够改善物理化学特性和气溶行为.
- 该NC证明了在体外对A549肺癌细胞的增强疗效,以及在体内有利的肺积累,具有良好的安全性.
- 可吸入的向纳米载体通过增强药物输送和减少全身毒性来改善肺癌治疗,这是一种有前途的战略.
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